FEATURES

FAMILY

D-isomer specific 2-hydroxyacid dehydrogenase family

DESCRIPTION

Also known as SERA_HUMAN, PHGDH, PGDH3. Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHGDH

D-3-phosphoglycerate dehydrogenase

PHGDH

Molecular Synopsis