FEATURES

FAMILY

DESCRIPTION

Also known as IRAK2_HUMAN, IRAK2. Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IRAK2

Interleukin-1 receptor-associated kinase-like 2

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

IRAK2

Structural Ligandability

Domains Chains

Distribution