FEATURES

FAMILY

DESCRIPTION

Also known as DENR_HUMAN, DENR, DRP1. May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. Interacts with MCTS1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DENR

Density-regulated protein

DENR

Molecular Synopsis