FEATURES

DESCRIPTION

Also known as DCX_HUMAN, DCX, DBCN, LISX. Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. Interacts with tubulin (PubMed:27292316). Interacts with USP9X (PubMed:24607389).

EXTERNAL LINKS

DCX

Mutations

Mutation(s) distribution

Mutations table