FEATURES

FAMILY

DESCRIPTION

Also known as ORC5_HUMAN, ORC5, ORC5L. Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ORC5

Origin recognition complex subunit 5

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

ORC5

Structural Ligandability

Domains Chains

Distribution