FEATURES

FAMILY

class-III pyridine nucleotide-disulfide oxidoreductase family

DESCRIPTION

Also known as NCPPR_PYRHO, PH0572. Catalyzes the NAD(P)H-dependent reduction of polysulfide, CoA-polysulfides, and CoA persulfide, as well as the reduction of a range of other small persulfides, including TNB and glutathione persulfides. The likely in vivo substrates are di-, poly-, and persulfide derivatives of coenzyme A, although polysulfide itself is also efficiently reduced (PubMed:23530771). Shows coenzyme A disulfide reductase (CoADR) activity with both NADH and NADPH, with a preference for NADPH (PubMed:15720393). May also play a role in the reduction of elemental sulfur (PubMed:23530771). Homodimer (PubMed:23530771). Homotetramer (PubMed:15720393).

Also known as NCPPR_PYRHO, PH0572. Catalyzes the NAD(P)H-dependent reduction of polysulfide, CoA-polysulfides, and CoA persulfide, as well as the reduction of a range of other small persulfides, ...

EXTERNAL LINKS

PH0572

Mutations

Mutation(s) distribution

Mutations table