FEATURES

DESCRIPTION

Also known as REG6_PYRHO, fl11. DNA-binding protein involved in the repression of transcription of a large number of genes, thereby arresting growth, in response to environmental changes (PubMed:14976242, PubMed:18073105). Binding sites are identified in promoters of approximately 200 transcription units, including genes involved in ATP synthesis, transmembrane transport, translation and DNA synthesis (PubMed:18073105). Homodimer (PubMed:14976242, PubMed:18073105, PubMed:19004003). Binds DNA as a dimer and an octamer (PubMed:18073105, PubMed:19004003). The octamer formed with lysine is stable in solution, but the octamer formed with arginine is unstable without DNA (PubMed:19004003). When crystallized in the absence of DNA, dimers are assembled into helical cylinders with six dimers per turn (PubMed:14976242). In solution, predominantly behaves as a dimer (PubMed:14976242).

EXTERNAL LINKS

fl11

Mutations

Mutation(s) distribution

Mutations table