FEATURES

FAMILY

DESCRIPTION

Also known as TYW4_HUMAN, LCMT2, KIAA0547, TYW4. Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. Interacts with RNF144B/IBRDC2.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

LCMT2

tRNA wybutosine-synthesizing protein 4

ligandability Mutations

LCMT2

Molecular Synopsis