FEATURES

FAMILY

DESCRIPTION

Also known as OGA_HUMAN, OGA, HEXC, KIAA0679, MEA5, MGEA5. Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714)., Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).

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EXTERNAL LINKS

OGA

Protein O-GlcNAcase

ligandability Mutations

Molecular Synopsis
Structural Ligandability

Structural Ligandability

Domains Chains

57 chains assessed

15 chains not associated with a domain

OGA

Structural Ligandability

Domains Chains

Distribution