FEATURES

FAMILY

DESCRIPTION

Also known as REV3L_HUMAN, REV3L, POLZ, REV3. Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

REV3L

DNA polymerase zeta catalytic subunit

REV3L

Molecular Synopsis