FEATURES

FAMILY

DESCRIPTION

Also known as RNH1_HUMAN, RNASEH1, RNH1. Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RNASEH1

Ribonuclease H1

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

RNASEH1

Structural Ligandability

Domains Chains

Distribution