FEATURES

FAMILY

DESCRIPTION

Also known as SMC3_XENLA, smc3, smc3l1. Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Forms a heterodimer with SMC1 in cohesin complex. The cohesin complex is composed of the SMC1 and SMC3 heterodimer attached via their SMC hinge domain, RAD21 which link them, and one STAG protein (STAG1 or STAG2), which interacts with RAD21.

EXTERNAL LINKS

smc3

Mutations

Mutation(s) distribution

Mutations table