FEATURES

FAMILY

DESCRIPTION

Also known as UBE4B_HUMAN, UBE4B, HDNB1, KIAA0684, UFD2. Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (PubMed:17369820). Interacts with VCP/p97. Interacts with STUB1/CHIP and UNC45B.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBE4B

Mutations

Mutation(s) distribution

Mutations table