FEATURES

FAMILY

ligand-gated ion channel (TC 1.A.9) family

DESCRIPTION

Also known as 5HT3B_HUMAN, HTR3B. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

HTR3B

5-hydroxytryptamine receptor 3B

ligandability Mutations

HTR3B

Molecular Synopsis