FEATURES

FAMILY

DESCRIPTION

Also known as SMC2_HUMAN, SMC2, CAPE, SMC2L1. Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.

EXTERNAL LINKS

SMC2

Structural maintenance of chromosomes protein 2

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

SMC2

Structural Ligandability

Domains Chains

Distribution