FEATURES

FAMILY

class-II aminoacyl-tRNA synthetase family

DESCRIPTION

Also known as SYFM_HUMAN, FARS2, FARS1. Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FARS2

Phenylalanine--tRNA ligase, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

Search Mutation