FEATURES

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

DESCRIPTION

Also known as ADCY5_HUMAN, ADCY5. Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). Interacts with GNAS, GNB1 and GNG2 (PubMed:26206488). Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1 (PubMed:15385642).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADCY5

Adenylate cyclase type 5

ADCY5

Molecular Synopsis