FEATURES

FAMILY

purine/pyrimidine phosphoribosyltransferase family

DESCRIPTION

Also known as HPRT_HUMAN, HPRT1, HPRT. Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HPRT1

Hypoxanthine-guanine phosphoribosyltransferase

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

HPRT1

Structural Ligandability

Domains Chains

Distribution