FEATURES

FAMILY

class-I pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as AATM_CHICK, GOT2. Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

GOT2

Aspartate aminotransferase, mitochondrial

Mutations

Mutation(s) distribution

Mutations table

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