FEATURES

FAMILY

DESCRIPTION

Also known as PGK1_HUMAN, PGK1, PGKA. Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1, 3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PGK1

Mutations

Mutation(s) distribution

Mutations table