FEATURES

DESCRIPTION

Also known as CHTB_VIBCH, ctxB, toxB. The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge.

EXTERNAL LINKS

uniprot
enzyme classification

ctxB

Cholera enterotoxin subunit B

ctxB

Molecular Synopsis