FEATURES

FAMILY

DESCRIPTION

Also known as CO3A1_HUMAN, COL3A1. Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines. Interacts with ADGRG1 (PubMed:28258187).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

COL3A1

Mutations

Mutation(s) distribution

Mutations table