FEATURES

FAMILY

DESCRIPTION

Also known as BZLF1_EBVB9, BZLF1. Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1). Homodimer (PubMed:28158710). Interacts with human UBN1, CRTC2 and RACK1. Interacts (via N-terminus) with human PAX5 (via N-terminus); this interaction inhibits BZLF1-mediated lytic viral reactivation (PubMed:23678172).

EXTERNAL LINKS

uniprot
enzyme classification

BZLF1

Mutations

Mutation(s) distribution

Mutations table