FEATURES

FAMILY

DESCRIPTION

Also known as CAPSD_BPMS2, CAPSD. Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins) (PubMed:8254664, PubMed:18662904). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome (PubMed:9469847, PubMed:26608810, PubMed:7523953). The capsid contains also 1 copy of the A2 maturation protein (PubMed:8254664)., Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is the result of capsid protein interaction with an RNA hairpin which contains the replicase ribosome-binding site. Homodimer (PubMed:8254664, PubMed:7788292, PubMed:19521994). The capsid proteins form dimers that assemble by group of 5. Twelve such pentamers are linked together with free dimers (PubMed:8254664). The homodimers binds to the viral RNA via an operator hairpin, but also to many other RNA sequences in the viral genome; this interaction probably shifts the virus from the replicative to the assembly phase and ensures specific encapsidation of the viral genome (PubMed:12948491).

EXTERNAL LINKS

CAPSD

Structural Ligandability

Domains Chains

Distribution