FEATURES

FAMILY

cation transport ATPase (P-type) (TC 3.A.3) family

DESCRIPTION

Also known as AT2A1_RABIT, ATP2A1. Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:10914677, PubMed:11438520, PubMed:15189864, PubMed:29081402, PubMed:18075584, PubMed:24270570, PubMed:23996003). Contributes to calcium sequestration involved in muscular excitation/contraction. Interacts with sarcolipin (SLN) (PubMed:29081402, PubMed:23455422, PubMed:23455424). Interacts with phospholamban (PLN) (PubMed:8428955, PubMed:10551848, PubMed:29081402, PubMed:23996003). Interacts with myoregulin (MRLN) (By similarity). Interacts with DWORF (By similarity). Interacts VMP1 (By similarity).

EXTERNAL LINKS

ATP2A1

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

ATP2A1

Molecular Synopsis