FEATURES

FAMILY

DESCRIPTION

Also known as SCN2A_RAT, Scn2a, Scn2a1. Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). Heterooligomer of a large alpha subunit and a smaller beta subunit. Heterooligomer with SCN2B or SCN4B; disulfide-linked (PubMed:26894959). Heterooligomer with SCN1B or SCN3B; non-covalently linked. Interacts with NEDD4L. Interacts with CALM. Interacts with the conotoxin GVIIJ (PubMed:24497506). Interacts with the scorpion toxin BMK M1 (PubMed:20678086).

EXTERNAL LINKS

Scn2a

Mutations

Mutation(s) distribution

Mutations table