FEATURES

FAMILY

DESCRIPTION

Also known as DAPDH_CORGL, ddh. Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D, L-2, 6-diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2, 6-diaminopimelate, since L, L-2, 6-diaminopimelate, D, D-2, 6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L-methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L-tryptophan, L-ornithine, L-histidine, L-arginine, D-glutamate, and D-alanine are not substrates for the oxidative deamination reaction. Can use NAD(+) only poorly since the activity observed in the presence of NAD(+) is about 3% of that with NADP(+). Homodimer.

EXTERNAL LINKS

ddh

Meso-diaminopimelate D-dehydrogenase

ddh

Molecular Synopsis