FEATURES

FAMILY

DESCRIPTION

Also known as BIRA_ECOLI, birA, bioR, dhbB. Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. Monomer in solution. Interacts with BCCP. Homodimerizes to bind DNA. Interaction with the corepressor bio-5'-AMP increases dimerization.

EXTERNAL LINKS

uniprot
enzyme classification

birA

Bifunctional ligase/repressor BirA

birA

Molecular Synopsis