FEATURES

FAMILY

DESCRIPTION

Also known as DPOLB_HUMAN, POLB. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Interacts with FAM168A (PubMed:25260657).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

POLB

Mutations

Mutation(s) distribution

Mutations table