FEATURES

FAMILY

calcium channel alpha-1 subunit (TC 1.A.1.11) family

DESCRIPTION

Also known as CAC1S_RABIT, CACNA1S, CACH1, CACNL1A3. Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle (PubMed:9465115, PubMed:15201141, PubMed:25548159, PubMed:27621462, PubMed:29078335, PubMed:29467163). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction (PubMed:9465115 PubMed:15201141, PubMed:27621462). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1 (PubMed:3037387, PubMed:27621462, PubMed:15134636, PubMed:25667046, PubMed:26680202, PubMed:27580036). The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2 (PubMed:15134636, PubMed:25667046, PubMed:26680202, PubMed:27580036). CACNA1S channel activity is modulated by the auxiliary subunits (CACNB1 or CACNB2, CACNG1 and CACNA2D1). Interacts with DYSF and JSRP1 (By similarity). Interacts with RYR1 (PubMed:10388749). Interacts with STAC, STAC2 and STAC3 (via their SH3 domains) (PubMed:28112192, PubMed:29078335, PubMed:29467163). Interaction with STAC3 promotes expression at the cell membrane (PubMed:25548159, PubMed:29467163). Interaction with STAC2 promotes expression at the cell membrane, but with much lower efficiency than STAC3. Interaction with STAC1 leads to very low levels expression at the cell membrane, much less than the levels observed upon interaction with STAC3 and STAC2 (PubMed:29467163). Interacts with CALM (By similarity).

EXTERNAL LINKS

CACNA1S

Voltage-dependent L-type calcium channel subunit alpha-1S

CACNA1S

Molecular Synopsis