FEATURES

FAMILY

DESCRIPTION

Also known as CATD_HUMAN, CTSD, CPSD. Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain (PubMed:8393577, PubMed:1426530). Interacts with ADAM30; this leads to activation of CTSD (PubMed:27333034). Interacts with GRN; stabilizes CTSD; increases its proteolytic activity (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CTSD

Cathepsin D

CTSD

Molecular Synopsis