FEATURES

FAMILY

receptors of complement activation (RCA) family

DESCRIPTION

Also known as DAF_HUMAN, CD55, CR, DAF. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829)., (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5., (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable)., (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Interacts with ADGRE5 (PubMed:11297558).

EXTERNAL LINKS

CD55

Mutations

Mutation(s) distribution

Mutations table