FEATURES

FAMILY

DESCRIPTION

Also known as ELNE_HUMAN, ELANE, ELA2. Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Interacts with NOTCH2NL.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ELANE

Neutrophil elastase

Mutations

Mutation(s) distribution

Mutations table

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