FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as ADH4_HUMAN, ADH4. Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z, 8Z, 11Z, 14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADH4

All-trans-retinol dehydrogenase [NAD(+)] ADH4

ADH4

Molecular Synopsis