FEATURES

DESCRIPTION

Also known as ODPA_HUMAN, PDHA1, PHE1A. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDHA1

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

PDHA1

Molecular Synopsis