FEATURES

FAMILY

DESCRIPTION

Also known as AERA_AERHY, aerA. Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and host cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter. Homodimer in solution; homoheptamer in the host membrane. After binding to GPI-anchored proteins in target membranes and proteolytic removal of the C-terminal propeptide, the protein assembles into a heptameric pre-pore complex. A further conformation change leads to insertion into the host membrane.

EXTERNAL LINKS

uniprot
enzyme classification

aerA

Mutations

Mutation(s) distribution

Mutations table