FEATURES

FAMILY

DESCRIPTION

Also known as SPRC_HUMAN, SPARC, ON. Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPARC

Molecular Synopsis