FEATURES

FAMILY

DESCRIPTION

Also known as C1S_HUMAN, C1S. C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

C1S

Complement C1s subcomponent

Mutations

Mutation(s) distribution

Mutations table

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