FEATURES

FAMILY

DESCRIPTION

Also known as IFI6_HUMAN, IFI6, G1P3. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571). Interacts with CIB1; the interaction is direct.

Also known as IFI6_HUMAN, IFI6, G1P3. Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IFI6

Interferon alpha-inducible protein 6

IFI6

Molecular Synopsis