FEATURES

FAMILY

DESCRIPTION

Also known as UCHL1_HUMAN, UCHL1. Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (PubMed:9774100, PubMed:8639624, PubMed:12408865, PubMed:23359680). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (PubMed:12408865). Monomer. Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UCHL1

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1

Molecular Synopsis