FEATURES

FAMILY

DESCRIPTION

Also known as HLGA_STAAM, hlgA, hlg2. Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. HlgA (class S) associates with HlgB (class F) thus forming an AB toxin in strains producing both gamma-hemolysins and leukocidins. HlgA and LukF-PV can also form a complex (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

hlgA

Gamma-hemolysin component A

hlgA

Molecular Synopsis