FEATURES

DESCRIPTION

Also known as FADR_ECOLI, fadR, oleR, thdB. Multifunctional regulator of fatty acid metabolism (PubMed:1569108, PubMed:8446033, PubMed:9388199, PubMed:11859088, PubMed:19854834, PubMed:21276098). Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE (PubMed:9388199). Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes (PubMed:9388199). Homodimer (PubMed:9388199, PubMed:11013219, PubMed:11296236, PubMed:11279025). Binding of acyl-CoA alters conformation of the dimer, separating the DNA-binding regions and disrupting DNA-binding (PubMed:11296236).

Also known as FADR_ECOLI, fadR, oleR, thdB. Multifunctional regulator of fatty acid metabolism (PubMed:1569108, PubMed:8446033, PubMed:9388199, PubMed:11859088, PubMed:19854834, PubMed:2127609 ...

EXTERNAL LINKS

fadR

Fatty acid metabolism regulator protein

fadR

Molecular Synopsis