FEATURES

FAMILY

Orn/Lys/Arg decarboxylase class-I family

DESCRIPTION

Also known as LDCI_ECOLI, cadA, ldcI. Inducible lysine decarboxylase that catalyzes the proton-dependent decarboxylation of L-lysine to produce the polyamine cadaverine and carbon dioxide (PubMed:4590109). Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation (PubMed:17209032). Homodecamer; built of five dimers associated in a 5-fold symmetrical double-ring (PubMed:27080013, PubMed:16301313, PubMed:4590109, PubMed:21278708, PubMed:25097238). Interacts (via C-terminus) with RavA (PubMed:16301313, PubMed:25097238, PubMed:27080013).

EXTERNAL LINKS

uniprot
enzyme classification

cadA

Inducible lysine decarboxylase

cadA

Molecular Synopsis