FEATURES

FAMILY

purine/pyrimidine phosphoribosyltransferase family

DESCRIPTION

Also known as HPRT_ECOLI, hpt. Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

hpt

Hypoxanthine phosphoribosyltransferase

Mutations

Mutation(s) distribution

Mutations table

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