FEATURES

FAMILY

cysteine synthase/cystathionine beta-synthase family

DESCRIPTION

Also known as CYSK_ECOLI, cysK, cysZ. (Microbial infection) In addition to its role in cysteine synthesis, stimulates the tRNase activity of CdiA-CT from E.coli strain 536 / UPEC; stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required for CDI of strain EC93, whose toxin may function by forming inner cell membrane pores (PubMed:22333533). CysK stabilizes CdiA-CT, allowing it to bind tRNA substrate; neither CdiA-CT nor CysK bind tRNA alone in vitro (PubMed:27531961). Homodimer (Ref.6, PubMed:27531961). Forms a cysteine synthase complex with 1 copy of CysE (By similarity).

EXTERNAL LINKS

cysK

Cysteine synthase A

cysK

Molecular Synopsis