FEATURES

FAMILY

DESCRIPTION

Also known as RPOE_ECOLI, rpoE, sigE. Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released (PubMed:7889935, PubMed:2691330, PubMed:9159522, PubMed:9159523). Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock (PubMed:7889935) and oxidative stress; it controls protein processing in the extracytoplasmic compartment. The 90 member regulon consists of the genes necessary for the synthesis and maintenance of both proteins and LPS of the outer membrane (PubMed:7889934, PubMed:11274153, PubMed:16336047). Indirectly activates transcription of csrB and csrC, 2 sRNAs that antagonize translational regulator CsrA, linking envelope stress, the stringent response and the catabolite repression systems (PubMed:28924029). Interacts transiently with the RNAP catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNAP holoenzyme that can initiate transcription (PubMed:12016219, PubMed:12718891, PubMed:7889935, PubMed:2691330). Interacts 1:1 with anti-sigma-E factor RseA which prevents binding to RNAP catalytic core (PubMed:9159522, PubMed:9159523, PubMed:11777003, PubMed:12016219, PubMed:15371343, PubMed:12718891). An N-terminal (residues 1-108) RseA sigma-E complex also interacts with SspB (PubMed:15371343).

EXTERNAL LINKS

rpoE

Mutations

Mutation(s) distribution

Mutations table