FEATURES

FAMILY

DESCRIPTION

Also known as CKR1B_CONRO, CKR1B. Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has antagonist activity on the NR2B/GRIN2B subunit (IC(50)=0.1 uM) (PubMed:22594498, PubMed:26048991, PubMed:27981829). In vivo, when delivered into the brain, is active has anticonvulsant activity in the model of epilepsy in mice (PubMed:22594498).

EXTERNAL LINKS

uniprot
enzyme classification

CKR1B

Conantokin Rl-B

Mutations

Mutation(s) distribution

Mutations table

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