FEATURES

FAMILY

DESCRIPTION

Also known as H3Y2_HUMAN, H3Y2. Primate-specific variant histone H3, which constitutes a core component of nucleosomes (PubMed:20819935). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable). The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:20819935). The octamer wraps approximately 147 bp of DNA (Probable).

EXTERNAL LINKS

H3Y2

Histone H3.X

Mutations

Mutation(s) distribution

Mutations table

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