FEATURES

FAMILY

DESCRIPTION

Also known as IL8_HUMAN, CXCL8, IL8. IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521).

Also known as IL8_HUMAN, CXCL8, IL8. IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is release ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CXCL8

Mutations

Mutation(s) distribution

Mutations table