FEATURES

FAMILY

herpesviridae inner tegument protein family

DESCRIPTION

Also known as ITP_HHV11, UL37. Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex (By similarity). Plays a role in microtubule-based retrograde axonal transport to promote neuroinvasion (PubMed:29216315). Plays also a role in the inhibition of host immune response by acting as a viral deamidase (PubMed:27866900). Deamidates host DDX58/RIG-I on two asparagines which becomes unable to sense viral dsRNA. In turn, its ability to trigger antiviral immune response and restrict viral replication is inhibited (PubMed:27866900). Deamidates also a critical asparagine on host CGAS which abolishes cGAMP synthesis and downstream innate immune activation (PubMed:30092200). Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus) (By similarity) (PubMed:18787001, PubMed:24725933). Interacts with host DST (PubMed:23269794). Interacts with host DDX58; this interaction inhibits DDX58 activation (PubMed:27866900). Interacts with host CGAS; this interaction inhibits host CGAS activation (PubMed:30092200).

EXTERNAL LINKS

UL37

Inner tegument protein

UL37

Molecular Synopsis